Superstructures of water-dispersive hydrophobic nanocrystals: specific properties

nanocrystal shells (colloidosomes) filled or unfilled with Au 3D superlattices and also spherical solid crystal structures are called supraballs. Colloidosomes and supraballs in contact with cancer cells increase the density of nanocrystals in lysosomes and near the lysosomal membrane. Importantly, the structure of their organization is maintained in lysosomes for up to 8 days after internalization, while the initially dispersed hydrophilic nanocrystals are randomly aggregated. These two structures act as nanoheaters. Indeed, due to the dilution of the metallic phase, the penetration depth of visible light is much greater than that of homogeneous metallic nanoparticles of similar size. This allows for a high average heat load overall. Thus, the organic matrix acts as an internal reservoir for efficient energy accumulation within a few hundred picoseconds. A similar behavior was observed with colloidosomes, supraballs and "egg" structures, making these superstructures universal nanoheaters, and the same behavior is not observed when they are not dispersed in water (dried and deposited on a substrate). Note that colloidosomes and supraballs trigger local photothermal damage inaccessible to isolated nanocrystals and not predicted by global temperature measurements.