Staying in shape: The second and third generations of a new dendron system switch from left-handed to right-handed helical conformations upon a change in solvent from THF to water (picture; left). This inversion occurs in tandem with conformational shifts about the OCCO bonds of a subset of terminating glycol chains, from gauche,gauche+,anti to anti,gauche−,anti (picture; right).
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Hofacker et al. (2005) studied this question.
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