Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 17, 2021Cardiovascular DiabetologyOpen Access

A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Aspirin has inconsistent effects on outcomes in diabetes and the optimal dosing regimen remains unclear.

Does aspirin 300 mg once daily compared to 75 mg once daily improve platelet inhibition and fibrin clot dynamics in patients with type 1 diabetes versus healthy controls?

Population

48 participants with type 1 diabetes and 48 healthy controls

Comparison

Aspirin 75 mg once-daily vs aspirin 300 mg once-daily

Design

Open-label crossover randomised controlled trial

Authors

WPWilliam A. ParkerRSRebecca SagarZKZeyad Kurdee

Discussion

Loading...

Member takes

Overview

Higher aspirin doses fail to fully restore efficacy in poorly controlled T1D; supports glycaemic optimization to enhance antithrombotic effects in future trials.

Structured PICO

Does aspirin 300 mg once daily compared to 75 mg once daily improve platelet inhibition and fibrin clot dynamics in patients with type 1 diabetes versus healthy controls?

P
Population
96 adults (48 with type 1 diabetes treated with insulin only, 48 healthy controls), aged 18-50 years, without prior antithrombotic treatment or significant comorbidities. 91 completed the study (45 patients with T1D and 46 controls).
I
Intervention
Aspirin 300 mg oral once daily for 14 days (administered in a crossover design)
C
Comparator
Aspirin 75 mg oral once daily for 14 days (administered in a crossover design)
O
Outcome
Change in maximum platelet aggregation (maxPA) response to collagen (2 µg/mL) from start to end of each treatment period compared between patients with T1D and controls for each aspirin regimensurrogate

Elevated HbA1c in type 1 diabetes attenuates the antiplatelet and profibrinolytic effects of aspirin, suggesting that strict glycemic control is necessary to optimize antithrombotic efficacy.

Limitations

  • Corrections for multiple tests were not made, making secondary and exploratory analyses hypothesis-generating only
  • Did not investigate clot permeability
  • Did not assess counteractive effects of higher-dose aspirin on endothelial prostacyclin release, gastroduodenal integrity, and haemostasis

Cite This Study

Parker et al. (2021) studied this question.

synapsesocial.com/papers/6a70967eac440176ef293f6dhttps://doi.org/10.1186/s12933-021-01427-y
View Full Paper
Ask AI
Bookmark
Share