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Experimental study demonstrates airborne delivery of attenuated BCG confers protective immunity against tuberculosis in guinea pigs, indicating strain-dependent vaccine efficacy.
Inhalation of very small numbers of living attenuated (BCG) organisms and their multiplication in guinea pigs results in the development of acquired resistance against subsequent airborne infection with virulent tubercle bacilli. Different strains of BCG have differing capacities to immunize by this means.
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Cohn et al. (1958) studied this question.
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