Answers are grounded in this paper and cite their sources.
Chitosan/poly(ethylene glycol) blends were crosslinked by the nontoxic genipin as a crosslinker to produce the pH‐responsive hydrogels. The pH‐responsive swelling and releasing behavior of chitosan/poly(ethylene glycol) hydrogels was studied by varying the contents of poly(ethylene glycol) (PEG) and genipin, and the molecular weights of PEG. The drug release increased as the pH of the medium decreased, because the protonation of amino acids in chitosan chains at the acidic condition caused the higher swelling of hydrogels. The drug release increased as the content of PEG increased, because the larger pores were formed in the hydrogel and the higher swelling of matrix was obtained. The drug release decreased with the increase of the content of genipin, because the higher degree of crosslinking impeded the diffusion of drug from the hydrogel matrix.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: