Why the study?
Impaired cerebral and spinal venous drainage from extracranial outflow obstruction was considered a possible contributor to neurodegenerative disease pathogenesis and clinical manifestations.
Does bilateral jugular veins occlusion induce clinical symptoms and histological brain alterations in mice?
Does bilateral jugular veins occlusion induce clinical symptoms and histological brain alterations in mice?
Bilateral jugular vein occlusion in mice alters cerebral hemodynamics and elicits a mild inflammatory process with brain edema and micro-hemorrhages, but without significant neurological symptoms or demyelination.
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Greco et al. (2020) studied this question.
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