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July 10, 2017Open Access

Neurotropism of enterovirus D68 isolates is independent of sialic acid and is not a recently acquired phenotype

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Population

Organotypic mouse brain slice cultures from postnatal day 1 to 10 C57/Black 6 mice, human iPSC-derived…

Comparison

Infection with multiple isolates of enterovirus… vs Uninfected cultures or poliovirus type 1…

Design

Preclinical

Follow-up

up to 96 hours post-infection

Authors

ARAmy RosenfeldAWAudrey L. WarrenVRVincent R. Racaniello

Discussion

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Overview

EV-D68 association with AFM/AFP may inform surveillance; leaves open causality and needs prospective validation.

Structured PICO

P
Population
Organotypic mouse brain slice cultures from postnatal day 1 to 10 C57/Black 6 mice, human iPSC-derived cortical neurons and astrocytes, and mouse cell lines (MEF, N2A).
I
Intervention
Infection with multiple isolates of enterovirus D68 (EV-D68) from 1962 to 2014 (Fermon, Rhyne, NY, 947, 949, 952, 953, 956).
C
Comparator
Uninfected cultures or poliovirus type 1 infection.
O
Outcome
Viral replication in neurons and astrocytes, and dependence on sialic acid for infection.

EV-D68 isolates from multiple lineages are neurotropic in mouse and human models independent of sialic acid binding, suggesting neurotropism is an intrinsic, not recently acquired, viral property.

Cite This Study

Rosenfeld et al. (2017) studied this question.

synapsesocial.com/papers/6a7098fa8031ec7bb1dc73d7https://doi.org/10.1101/161778
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