November 1, 1994Journal of VirologyOpen Access

Identification and characterization of the cell surface 70-kilodalton sialoglycoprotein(s) as a candidate receptor for encephalomyocarditis virus on human nucleated cells

View Full Paper

Ask AI

Bookmark

Population

HeLa and K562 cell lines (human nucleated cells susceptible to encephalomyocarditis virus infection)

Comparison

Encephalomyocarditis virus attachment and… vs Nonpermissive K562 D clone cells and human…

Design

Preclinical

Authors

YJYanling JinRoche (Canada)IPI. U. PardoeMoseley Hall Hospital ABA. T. H. BurnessMemorial University of Newfoundland

Discussion

Member takes

Implication

No immediate clinical implications; leaves open functional validation of the 70-kDa sialoglycoprotein as EMCV receptor in humans.

Structured PICO

Population

HeLa and K562 cell lines (human nucleated cells susceptible to encephalomyocarditis virus infection)

Intervention

Encephalomyocarditis (EMC) virus attachment and biochemical characterization (including treatment with trypsin, cycloheximide, proteases, neuraminidases, and lectins)

Comparator

Nonpermissive K562 D clone cells and human erythrocytes

Outcome

Identification and characterization of the EMC virus receptor on human nucleated cells

Identifies a 70-kDa cell surface sialoglycoprotein as the candidate receptor for encephalomyocarditis virus on permissive human nucleated cells.

Cite This Study

Jin et al. (1994) studied this question.

synapsesocial.com/papers/6a7098fcfebe604dd7095e43 https://doi.org/10.1128/jvi.68.11.7308-7319.1994

View Full Paper

Ask AI

Bookmark