Metal complexes of boron‐bridged bisoxazolines (borabox ligands) were evaluated as catalysts for the Henry reaction. Copper(II) complexes induced high enantio‐ and diastereoselectivity in reactions with nitroethane and nitropropane. The amount of base added had a strong influence on the formation of the chiral complex and the enantioselectivity. Comparison with the corresponding dimethylmethylene‐bridged bisoxazoline and other privileged ligands showed that borabox was the most suitable ligand system for the enantio‐ and diastereoselective formation of nitroalcohols derived from nitropropane and aliphatic aldehydes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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Toussaint et al. (2008) studied this question.
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