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Exclusive reaction at the γ-position relative to nitrogen takes place between the urea derivative (2), M = MgBr, and electrophiles. The new reagent is readily prepared from (1) and MgBr2·ether and corresponds to a “propionaldehyde-homoenolate synthon”.2, M = Li, froms α- and γ-substituted products.
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Hassel et al. (1979) studied this question.
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