What question did this study set out to answer?

This study aims to evaluate the relationship between enzymatic estimates and histologic measurements of myocardial infarction size.

March 1, 1977CirculationOpen Access

The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion.

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Why the study?

Do enzymatic estimates of infarct size correlate with histologic measurements in a canine model of permanent coronary occlusion?

Population

14 conscious dogs with permanent occlusion of the circumflex coronary artery

Comparison

Enzymatic estimates of infarct size using serial… vs Histologic measurements of infarct size (HIS)

Design

Preclinical

Follow-up

5-6 days

Authors

CRCharles R. RoeThe University of Texas Southwestern Medical Center FCFrederick R. CobbAtrium Health Wake Forest Baptist CSC F StarmerElectrophysiology

Discussion

Member takes

Implication

Enzymatic estimates should not quantify infarct size in permanent occlusion models; leaves open whether refined assays improve histologic correlation in translational studies.

Key Points

This study aims to evaluate the relationship between enzymatic estimates and histologic measurements of myocardial infarction size.
Analyzed enzyme estimates (CKP, CKP-MM, CKP-MB, CKP-BB) and histologic measurements in 14 conscious dogs.
Performed regression analysis to assess correlation between enzymatic estimates and histologic size 5-6 days post-infarction.
Subgroup analysis focused on dogs with histologic infarct size less than 13 grams.
Regression showed poor correlation (r2 < 0.06) between enzyme estimates and histologic size for overall data.
Improved correlation (r2 = 0.42) found in subgroup analysis (HIS < 13 grams) using the Shell method.
Each method (Shell, Norris, Roberts) overestimated histologic infarct size, ranked as Shell > Norris > Roberts.

Structured PICO

Do enzymatic estimates of infarct size correlate with histologic measurements in a canine model of permanent coronary occlusion?

Population

14 conscious dogs with permanent occlusion of the circumflex coronary artery

Intervention

Enzymatic estimates (EE) of infarct size using serial CPK, CPK-MM, CPK-MB, and CPK-BB

Comparator

Histologic measurements of infarct size (HIS)

Outcome

Correlation between enzymatic estimates and histologic measurements of infarct sizesurrogate

Serum enzyme measurements (CPK and isoenzymes) poorly correlate with histologic infarct size in a canine model of permanent coronary occlusion, failing to distinguish small from large infarcts.

Cite This Study

Roe et al. (1977) studied this question.

synapsesocial.com/papers/6a709ac326a7f98052dd1495 https://doi.org/10.1161/01.cir.55.3.438

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Implication

Enzymatic estimates should not quantify infarct size in permanent occlusion models; leaves open whether refined assays improve histologic correlation in translational studies.

The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider