Population
Preclinical model (sodium channels)
Comparison
Alanine-scanning mutagenesis vs Wild type sodium channels
Design
Preclinical
Authors
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Identifies IVS6 residues critical for Na+ inactivation; leaves open therapeutic targeting in channelopathies pending human validation.
Residues near the intracellular end of segment IVS6 (Val-Ile-Leu) are critical for fast Na(+)-channel inactivation and may form part of the hydrophobic receptor site for the fast inactivation gate.
McPhee et al. (1994) studied this question.
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