Key result
Computer-aided fundus imaging software improves hypertensive risk classification by ~20% over expert visual inspection.
RCT
Double-blind
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The goal of the software proposed in this paper is to assist ophthalmologists in diagnosis and disease prevention, helping them to determine cardiovascular risk or other diseases where the vessels can be altered, as well as to monitor the pathology progression and response to different treatments. The performance of the tool has been evaluated by means of a double-blind study where its sensitivity, specificity, and reproducibility to discriminate between health fundus (without cardiovascular risk) and hypertensive patients has been calculated in contrast to an expert ophthalmologist opinion obtained through a visual inspection of the fundus image. An improvement of almost 20% has been achieved comparing the system results with the clinical visual classification.
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Morales et al. (2014) conducted an RCT in Hypertension and cardiovascular risk. Computer-aided diagnosis software for fundus image processing vs. Expert ophthalmologist visual inspection of fundus images was evaluated on Sensitivity, specificity, and reproducibility to discriminate between healthy fundus and hypertensive patients (Almost 20% improvement). Computer-aided diagnosis software for fundus image processing improved hypertensive risk classification by almost 20% compared to clinical visual inspection by an expert ophthalmologist.
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