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The pharmacological effects of acetaldehyde on the cardiovascular system, the liver, monoamine neurotransmitter metabolism, brain function and behaviour, and voluntary ethanol drinking are reviewed. The pharmacological effects of acetaldehyde, produced during the interaction of ethanol with the aldehyde dehydrogenase inhibitors disulfiram, calcium carbimide (calcium cyanamide), and 1-aminocyclopropanol (the pharmacologically active hydrolytic product of coprine) are discussed. The proposed involvement of acetaldehyde in the pharmacological effects of ethanol is critically assessed. The literature up to the end of 1981 has been reviewed.
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Brien et al. (1983) studied this question.
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