March 1, 1985British Journal of PharmacologyOpen Access

Pharmacological analysis of β‐adrenoceptor‐mediated agonism in the guinea‐pig, isolated, right atrium

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Population

Guinea-pig isolated right atrial preparation

Comparison

Experimental variation of total functional… vs Baseline/control responses to isoprenaline and…

Design

Preclinical

Authors

JBJ.W. BlackDulwich Community Hospital VGV.P. GerskowitchJames S. McDonnell Foundation PLP. LeffCreighton University

Discussion

Member takes

Implication

Supports operational model for receptor vs post-receptor effects in vitro; leaves open any clinical translation.

Structured PICO

Population

Guinea-pig isolated right atrial preparation

Intervention

Experimental variation of total functional concentration of receptors ([Ro]) using Bromoacetylalprenolol menthane (M-75) and concentration of agonist-occupied receptors for half-maximal effect (KE) using Cholera toxin

Comparator

Baseline/control responses to isoprenaline and dichloroisoprenaline

Outcome

Changes in E/[A] curve profiles (beta-adrenoceptor mediated chronotropic responses)surrogate

The operational model provides a conceptual framework for predicting and interpreting changes in E/[A] curve profiles from experimental interventions at both the receptor and post-receptor levels.

Cite This Study

Black et al. (1985) studied this question.

synapsesocial.com/papers/6a709f60a2d7cf2e39c2b095 https://doi.org/10.1111/j.1476-5381.1985.tb16161.x

View Full Paper

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Pharmacological analysis of β‐adrenoceptor‐mediated agonism in the guinea‐pig, isolated, right atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological analysis of β‐adrenoceptor‐mediated agonism in the guinea‐pig, isolated, right atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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