Analysis of Case-Control Studies of the Efficacy of Screening for Cancer: How Should We Deal with Tests Done in Persons with Symptoms?

N. S. Weiss

doi:10.1093/oxfordjournals.aje.a009407

June 15, 1998American Journal of EpidemiologyOpen Access

Analysis of Case-Control Studies of the Efficacy of Screening for Cancer: How Should We Deal with Tests Done in Persons with Symptoms?

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Key Points

To evaluate how diagnostic procedures performed in symptomatic individuals should be handled when analyzing case-control studies of cancer screening efficacy.
Assessed methodological frameworks for defining screening exposures within case-control study designs.
Examined the analytical consequences of conflating diagnostic testing prompted by symptoms with asymptomatic screening.
Identified that misclassifying diagnostic evaluations in symptomatic individuals as screening tests introduces substantial bias into efficacy estimates.
Demonstrated that restricting the exposure definition strictly to tests conducted in asymptomatic individuals preserves valid assessments of screening benefit.

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Implication

Methodological analysis reveals misclassification risks in case-control studies of cancer screening, highlighting the necessity of distinguishing screening tests from diagnostic evaluations.

Abstract

Noel S. Weiss; Analysis of Case-Control Studies of the Efficacy of Screening for Cancer: How Should We Deal with Tests Done in Persons with Symptoms?, American

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N. S. Weiss (1998) studied this question.

synapsesocial.com/papers/6a70a06726770c2b8de0a4ed https://doi.org/10.1093/oxfordjournals.aje.a009407

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Analysis of Case-Control Studies of the Efficacy of Screening for Cancer: How Should We Deal with Tests Done in Persons with Symptoms?

Key Points

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Implication

Abstract

Discussion

Cite This Study

Analysis of Case-Control Studies of the Efficacy of Screening for Cancer: How Should We Deal with Tests Done in Persons with Symptoms?

Key Points

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Implication

Abstract

Discussion

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