The description of Australia antigen by Blumberg, Alter, and Visnich in 1965, and the subsequent dis- covery of its association with hepatitis (Blumberg, Sutnick, and London, 1968) have stimulated re- newed interest in the disease. The antigen occurs in the serum during the acute phase of illness and seems to be closely associated with infectivity. In this review our knowledge of its properties will be dis- cussed first, then the various techniques for detecting it will be assessed, and lastly an attempt will be made to define the significance of the antigen in the pathogenesis and natural history of hepatitis.
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Yvonne E. Cossart (1971) studied this question.