Why the study?
Does tryptophan enhancement or depletion affect plasma catecholamine levels in healthy individuals?
Population
164 healthy men and women
Comparison
Tryptophan enhancement or tryptophan depletion… vs 'Sham day'
Design
RCT, Randomized to a tryptophan enhancement condition or a tryptophan…
Follow-up
2 days
Authors
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Tryptophan manipulation effects in healthy volunteers warrant clinical caution; leaves open serotonin's role in human sympathetic regulation.
Does tryptophan enhancement or depletion affect plasma catecholamine levels in healthy individuals?
Tryptophan enhancement and depletion alter plasma catecholamine levels, demonstrating that central nervous system serotonin exerts both inhibitory and excitatory effects on sympathetic nervous system activity in humans.
Boyle et al. (2018) studied this question.
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