Why the study?
Can 23Na MRI detect intracellular Na+ accumulation and water uptake during provocation-induced weakness in patients with muscle Na+ channelopathies?
Can 23Na MRI detect intracellular Na+ accumulation and water uptake during provocation-induced weakness in patients with muscle Na+ channelopathies?
23Na MRI can effectively detect provocation-induced intracellular Na+ accumulation in patients with muscle Na+ channelopathies, which correlates closely with membrane depolarization.
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23Na MRI may detect Na+ shifts in provoked weakness; leaves open diagnostic utility pending prospective trials.
Weber et al. (2006) studied this question.
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