Increased Vitamin A in Esophagus and Other Extrahepatic Tissues after Chronic Ethanol Consumption in the Rat

In rats fed ethanol (36% of total energy) for 1 month, vitamin A content of the esophageal mucosa was found to be increased 5-fold, compared to animals pair-fed an isocaloric control diet containing the same amount of vitamin A. Similar results were observed with diets of either lower vitamin A content or zinc supplementation. Significant increases of retinoids were also found in lungs, trachea, kidneys, and testes, but not in the eyes. These increases in extrahepatic tissues contrasted strikingly with the concomitant decrease in the liver and suggests that chronic ethanol consumption may be associated with some mobilization of vitamin A from the liver to other organs.