A study was made of the long-term tissue effects of certain polymers when embedded in the subcutaneous tissues of the abdominal wall of rats. Five of the 299 animals that survived 300 days or more developed malignant tumors at the site of the implants. The tumors included 4 spindle-cell sarcomas and 1 undifferentiated sarcoma. A benign fibroma was found about one implant.
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Russell et al. (1959) studied this question.