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February 10, 2020BMC Cardiovascular DisordersOpen Access

Plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs (pooled SMD 0.55, 95% CI 0.30-0.80, P<0.0001 at 24 h; SMD 0.70, 95% CI 0.27-1.13, P=0.001 at 48 h).

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Why the study?

Predicting MACEs offers significant clinical benefits in coronary artery disease, prompting an evaluation of the prognostic value of plasma von Willebrand factor levels.

Do elevated plasma von Willebrand factor levels predict major adverse cardiovascular events in patients with coronary artery disease?

Population

960 CAD patients with MACEs and 3224 controls without MACEs across 15 studies

Comparison

CAD patients with MACEs vs controls without adverse events

Design

Systematic review and meta-analysis

Authors

MFMengge FanXWXia WangXPXun Peng

Discussion

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Overview

Plasma vWF levels were associated with MACE risk in CAD; leaves open added prognostic value beyond standard scores in prospective cohorts.

Structured PICO

Do elevated plasma von Willebrand factor levels predict major adverse cardiovascular events in patients with coronary artery disease?

P
Population
4,184 patients with coronary artery disease (myocardial infarction, acute coronary syndrome, and stable CAD) from 15 cohort studies, including 960 patients who had MACEs and 3,224 controls without adverse events.
I
Intervention
Plasma von Willebrand factor (vWF) levels examined on admission, 24 h, and 48 h after admission
C
Comparator
Plasma vWF levels in CAD patients without MACEs
O
Outcome
Major adverse cardiovascular events (MACEs) or mortality following CADcomposite

Elevated plasma von Willebrand factor levels at 24 and 48 hours after admission may serve as an independent prognostic biomarker for major adverse cardiovascular events in patients with coronary artery disease.

Limitations

  • The number of studies of duration on 24 h or 48 h available for meta analyzes was relatively small
  • The articles included many types of coronary artery disease including acute coronary syndrome, myocardial infarction, angina, which may contributes to clinical heterogeneity
  • Detailed information regarding symptom duration was not available in several studies

Cite This Study

Fan et al. (2020) studied this question.

synapsesocial.com/papers/6a70a3f9febe604dd7096986https://doi.org/10.1186/s12872-020-01375-7
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