Recovery from Aplastic Anemia after Treatment with Cyclophosphamide

The prognosis for survival in severe aplastic anemia remains poor despite advances in management of patients with this condition over the past decade. Treatment with androgenic steroids has not been shown to be effective in pronounced bone-marrow aplasia.1 , 2 Bone-marrow transplantation is now a recognized form of therapy for patients with severe aplastic anemia. However, although increasing success is being reported as a result of transplantation with an HLA-compatible sibling's bone marrow, more than half the patients do not have compatible siblings.3 For some years, it has been speculated that immune processes may be involved in the pathogenesis of aplastic anemia . . .