Better than all the rest: Tertiary boronic esters, readily available using the lithiation–borylation reaction, have been converted into tertiary alkylamines in very high ee. The work has been applied to a short, modular, and fully stereocontrolled synthesis of the pharmaceutical igmesine and chiral 2,2-disubstituted piperidines.
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Bagutski et al. (2010) studied this question.
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