Parasite specific: The inhibition of myristoyl-CoA:protein N-myristoyltransferase (NMT) can lead to parasite death in culture. Herein we review recent work that supports the suitability of NMT as a parasite-specific drug target. The example shown illustrates the peptidomimetic compound 2, which is more stable, yet retains the Ser and Lys functional groups of compound 1 that are necessary for NMT inhibition.
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Bowyer et al. (2008) studied this question.
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