Why the study?
Anastomotic leaks following colorectal resection represent serious surgical complications, prompting a comparison of the integrity of end-to-side versus end-to-end anastomosis techniques.
Does end-to-side anastomosis improve leak pressure and time to leakage compared to end-to-end anastomosis in an ex vivo porcine colonic model?
Does end-to-side anastomosis improve leak pressure and time to leakage compared to end-to-end anastomosis in an ex vivo porcine colonic model?
In an ex vivo porcine model, end-to-side anastomosis demonstrated superior time to leakage and tissue expansion compared to end-to-end anastomosis, despite similar leak pressures.
Answers are grounded in this paper and cite their sources.
Novel ex vivo porcine model may refine leak testing; leaves open translation to human colorectal surgery.
Anastomotic leaks after colorectal resection are serious surgical complications. We have compared the integrity of two common colorectal anastomosis techniques, end-to-side (ES) and end-to-end (EE), to control specimens using a novel experimental setup that mimics anastomotic air leak tests, which are typically performed during surgeries. Freshly harvested porcine colonic sections from 23 F1 cross-species pigs were used. Pressure measurements and video imaging were used to monitor the ex vivo experiments on EE, ES, and Control specimens. Using EE (n = 16), ES (n = 12), and Control (n = 22) specimens, leak pressure was 282.6 ± 3.0 mm Hg for EE, 282.8 ± 2.6 mm Hg for ES, and 294.4 ± 12.1 for the Control. Time to leakage was 106.3 ± 28.1 s for EE, 263.9 ± 2127.0 s for ES, and 194.5 ± 90.2 s for the Control. We found that, while EE and ES have nearly identical leak pressures, ES was superior in terms of time to leakage and tissue expansion, which may explain why ES anastomoses have a lower clinical anastomotic leak rate. Two dependent variables representing stress and strain of colonic tissues were introduced. These variables showed ES was comparable to the Control. The experiments were simulated successfully using the finite element method (FEM). This research provides a reproducible ex vivo system with a corresponding FEM system to study the differences between anastomosis techniques and may help design anastomoses with lower leak rates and improve patient outcomes in colorectal surgeries.
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Fahmy et al. (2025) studied this question.
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