January 1, 1983The Japanese Journal of PhysiologyOpen Access

Ca-dependent outward currents in bullfrog myocardium.

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Population

Bullfrog atrial muscle

Comparison

Alterations in extracellular calcium… vs Baseline or alternative ionic/pharmacological…

Design

Preclinical

Authors

MGMasayosi GOTOKyushu University THTakako HYODOKyushu University KIKatsuko IkedaKyushu University

Discussion

Member takes

Implication

Characterizes Ca-sensitive currents in amphibian atrium; leaves open translation to mammalian or human electrophysiology.

Structured PICO

Population

Bullfrog atrial muscle

Intervention

Alterations in extracellular calcium concentration ([Ca]o) and application of pharmacological agents (Ba, TTX, Co, isoproterenol, Ca-free EGTA Ringer)

Comparator

Baseline or alternative ionic/pharmacological conditions

Outcome

Changes in instantaneous outward current (Ik1), inward background current (Ib), slow inward current (Isi), and delayed outward current (Iout)surrogate

This preclinical study characterizes and classifies calcium-dependent outward currents in bullfrog atrial muscle into three distinct electrophysiological components.

Cite This Study

GOTO et al. (1983) studied this question.

synapsesocial.com/papers/6a70a820c1a24a6142db8cd4 https://doi.org/10.2170/jjphysiol.33.837

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