Why the study?
The study aimed to investigate the expression changes of periostin in oral leukoplakia and oral squamous cell carcinoma, and analyze its significance in the development of oral squamous cell carcinoma.
Periostin is significantly overexpressed in oral leukoplakia and squamous cell carcinoma, correlating with disease severity and suggesting its potential as a diagnostic and prognostic biomarker.
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Supports periostin evaluation as OSCC biomarker; hypothesis-generating and requires prospective validation before clinical use.
Objective: This study aims to investigate the expression changes of periostin (PN or OSF-2) in oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC), and analyze its significance in the development of OSCC. Study Design: The expression of periostin was detected from tissue specimens and serum obtained from normal mucosa, OLK and OSCC by immunohistochemistry, enzyme-linked immunosorbent assay, and quantitative polymerase chain reaction. Results: Periostin was significantly overexpressed in OLK and OSCC, when compared with normal controls (p < 0.05). Furthermore, the overexpression of periostin was positively correlated with TNM stage, depth of invasion, and lymph node metastasis (p < 0.05). Conclusion: The overexpression of periostin may be involved in the carcinogenesis process of OLK, which may be used as a marker for detecting OLK. In addition, periostin serum levels can be used as a potential indicator of invasion and a prognosis target for OSCC.
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Guan et al. (2019) studied this question.
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