Why the study?
Does phospholemman phosphorylation limit intracellular Na+ and Ca2+ loading during beta-adrenergic stimulation in mouse ventricular myocytes?
Does phospholemman phosphorylation limit intracellular Na+ and Ca2+ loading during beta-adrenergic stimulation in mouse ventricular myocytes?
Phospholemman phosphorylation during beta-adrenergic stimulation tempers the rise in intracellular Na+ and cellular Ca2+ loading, which may limit calcium overload-induced arrhythmias.
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May limit Ca overload arrhythmias during beta-stimulation in mice; leaves open human relevance.
Despa et al. (2008) studied this question.
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