Electron microscopy of negatively stained samples indicates that caldesmon induces polymerization of G-actin into filaments. Polymerization takes place in a very low ionic strength solution and is accompanied by an increase of intensity of fluorescence of G-actin labelled with N-(1-pyrenyl)iodoacetamide. The effect of caldesmon is abolished by calmodulin in the presence of Ca2+.
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Gałązkiewicz et al. (1985) studied this question.
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