Return to the fold. Nucleic acids with four tandem cytidine-rich repeats can fold into a structure called the i-motif at acidic pH. The folding- and unfolding-rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i-motif formation by increasing the folding and decreasing the unfolding.
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Zhao et al. (2005) studied this question.
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