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March 6, 20250 citations

Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis

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Why the study?

Does SGLT2i therapy reduce hospitalization for non-rheumatic aortic valve disease in diabetic patients compared to sulphonylureas?

Population

60,344 diabetic patients from the Lombardy regional healthcare database starting second-line therapy…

Comparison

Sodium-glucose co-transporter 2 inhibitors as… vs Sulphonylureas (SU) as second-line therapy.

Design

Cohort

Follow-up

24 months

Authors

VVVincenza ValerioIMIlaria MassaiuMFMatteo Franchi

Discussion

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Member takes

Overview

SGLT2i merit study in AS; leaves open any effect on progression or outcomes.

Structured PICO

Does SGLT2i therapy reduce hospitalization for non-rheumatic aortic valve disease in diabetic patients compared to sulphonylureas?

P
Population
60,344 diabetic patients from the Lombardy regional healthcare database starting second-line therapy, matched 1:1 (n=30,172 per group) by age, sex, and multisource comorbidity score. Preclinical models included 62 human adult tricuspid aortic valves (36 with aortic stenosis, 26 controls) and CRISPR/Cas9-edited human valve interstitial cells.
I
Intervention
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) as second-line therapy. Preclinical in vitro experiments utilized dapagliflozin.
C
Comparator
Sulphonylureas (SU) as second-line therapy.
O
Outcome
Cumulative incidence of hospitalization for non-rheumatic aortic valve disease over a 24-month follow-up period.hard clinical

SGLT2 inhibitors are associated with a 40% lower rate of hospitalization for aortic valve disease compared to sulfonylureas in diabetic patients, a protective effect potentially mediated by SIRT1-dependent reduction in fibro-calcific processes.

Cite This Study

Valerio et al. (2025) studied this question.

synapsesocial.com/papers/6a70ab232163a0a01bc4e1d7https://doi.org/10.1101/2025.03.03.641336
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