Live birth following the transfer of a euploid blastocyst derived from monopronuclear zygote

The objective of the present study is to report a case of a live birth following the transfer of a blastocyst derived from monopronuclear zygote that was found to be an euploid by preimplantation genetic testing for aneuploidy (PGT-A). The study was conducted at a tertiary care-assisted reproductive technology center. A 35-year-old female with a secondary infertility, polycystic ovaries, and with the history of recurrent implantation failure underwent an in vitro fertilization cycle followed by a frozen embryo transfer cycle. The main outcome measure was clinical pregnancy and live birth. The patient was considered pregnant after obtaining a βhCG level of 1334 mIU/mL after 14 days following embryo transfer and delivered a healthy baby girl at 30 weeks by cesarean section. In this study, transfer of frozen-thawed monopronuclear-derived blastocyst that was detected euploid with PGT-A, resulted in a healthy live birth. Therefore, we suggest that embryos from monopronuclear zygotes should not be discarded but instead be screened by PGT-A to ascertain the euploid status, especially in the absence of bipronuclear-derived embryos.