THIS case report and the metabolic studies that accompany it are presented primarily because of their bearing on the pathologic physiology of Cushing's syndrome. The term “Cushing's syndrome” as used herein refers only to the clinical picture emphasized by Cushing. The term “Cushing's disease” will be used in a broader sense than we used it in previous publications so as to denote all cases of Cushing's syndrome in which an adrenal cortical tumor is not present. A married woman aged twenty-six years first registered at the Mayo Clinic on September 3, 1943. There was nothing remarkable in her past medical history. On June 23, 1941, she consulted her physician because she was eight weeks pregnant. At that time she weighed 110 pounds (50 Kg.). The blood pressure expressed in millimeters of mercury, was 100 systolic and 60 diastolic, and the patient seemed to be a normal pregnant woman. Pregnancy proceeded uneventfully until December 22, 1941, when she was delivered of a premature infant who died shortly after birth. On February 21, 1942, she had one scant menstrual period.
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Kepler et al. (1948) studied this question.