The study establishes sex-specific 99th percentile upper reference limits for hs-TnT in a healthy multi-ethnic Asian population, highlighting the need for gender-specific cutoffs in clinical practice.
Asian-specific hs-TnT 99P URLs are required to guide ACS evaluation; leaves open validation across diverse Asian cohorts.
Background: Cardiovascular disease is rising exponentially in Asian countries. High-sensitivity cardiac troponin-T (hs-TnT) is vital for evaluating acute coronary syndromes. Although hs-TnT has been available since 2010 and used widely in Asia-Pacific there is paucity of published literature on what constitutes expected hs-TnT concentrations as well as the 99 th percentile (99P) upper reference limits (URL) in Asians. Almost all the hs-TnT data has been derived on Western populations. Besides, very few studies encompass large enough reference cohorts to mitigate against outlier distortion of the URL.
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Aw et al. (2017) studied this question.
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