Key result
Conditioning, cyclosporine A, and adenosine emerge as promising strategies to reduce ischemic myocardial reperfusion injury.
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Prompt myocardial reperfusion reduces infarct size in patients experiencing coronary occlusion. However, its clinical value is limited because reperfusion also causes ischemic myocardial reperfusion injury (IMRI). Considerable research to reduce IMRI has been conducted. Three interventions appear to be promising: 1) myocardial conditioning, which consists of repetitive occlusions of coronary or other arteries prior to or at the time of myocardial reperfusion; 2) the administration of cyclosporine A; and 3) the administration of adenosine. A plan for the testing of these interventions in patients with acute myocardial infarction is described.
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Eugene Braunwald (2011) conducted a review in Acute myocardial infarction / ischemic myocardial reperfusion injury. Myocardial conditioning, cyclosporine A, or adenosine was evaluated on Myocardial infarct size / ischemic myocardial reperfusion injury. Myocardial conditioning, cyclosporine A, and adenosine are identified as three promising interventions to test for reducing ischemic myocardial reperfusion injury in acute myocardial infarction.
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