Key result
Albumin and norepinephrine improve arterial pressure in hemorrhagic fever shock via cardiac output and vascular resistance.
Observational
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The cardiac output during the shock phase of hemorrhagic fever was very low. Increases in mean arterial pressure resulted from therapy with albumin or norepinephrine. With the former, this increase was associated with an increased cardiac output; with the latter, an increase in peripheral resistance. During the hypertensive phase, patients were found to have an increased cardiac output if they were also oliguric, and a relatively normal cardiac output if diuresis had begun. Some of the hypertensive patients presented the clinical syndrome of the "hyperdynamic state"; this occurred almost exclusively during the oliguric phase and was associated with high cardiac output and metabolic acidosis.
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Entwisle et al. (1957) conducted an observational in Hemorrhagic fever. Albumin or norepinephrine therapy (and clinical phase of hemorrhagic fever) was evaluated on Hemodynamic alterations (cardiac output, mean arterial pressure, and peripheral resistance). Albumin and norepinephrine both increased mean arterial pressure in hemorrhagic fever shock via increased cardiac output and peripheral resistance, respectively.
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