Diuretic Action of Glycerol in Dogs.

Glycerol produced an osmotic diuresis when given intravenously to dogs. The magnitude of the diuresis was proportional to the increased urinary solute excretion, and urine sodium concentration ranged between 50 and 100 mM per L. When glycerol was given together with a mercurial diuretic there were additive effects on water excretion, but sodium excretion was not enhanced beyond that produced by the mercurial.