Clonal hematopoiesis (CH), defined by the acquisition of somatic mutations in hematopoietic stem cells, occurs in 20% to 30% of individuals .60 years and most frequently affects epigenetic regulator genes (DNMT3A, TET2, and ASXL1). CH is associated with a higher overall mortality and an approximately 10-fold risk for the development of hematologic malignancies. Reduced overall survival (OS) in individuals with CH is mainly caused by an increased rate of cardiovascular events. 2,3 4]
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Arends et al. (2021) studied this question.
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