Why the study?
Chronic kidney disease causes salt-sensitive hypertension, but interactions between dietary salt and the renin-angiotensin system are incompletely understood.
Does dietary salt modify the blood pressure response to renin-angiotensin inhibition in rats with CKD?
Does dietary salt modify the blood pressure response to renin-angiotensin inhibition in rats with CKD?
Dietary salt restriction is crucial to maintain the efficacy of renin-angiotensin system inhibitors, and mineralocorticoid receptor blockade remains effective for hypertension even on a high-salt diet in CKD.
Chronic kidney disease (CKD) causes salt-sensitive hypertension, but the interactions between dietary salt and the renin-angiotensin system are incompletely understood. In rats with CKD on a normal-salt diet targeting aldosterone, the mineralocorticoid receptor (MR) and especially angiotensin II reduced blood pressure. On a high-salt diet, however, only MR blockade attenuated hypertension. These results reiterate the importance of dietary salt restriction to maintain renin-angiotensin system inhibitor efficacy and specify the MR as a target in CKD.
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Bovée et al. (2021) studied this question.
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