Transthoracic echocardiography is a feasible and reproducible method for assessing haemodynamics in baboons, successfully detecting expected physiological changes during pregnancy.
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Supports echocardiography for baboon pregnancy hemodynamics; leaves open translation to human clinical practice.
BACKGROUND: To determine systolic and diastolic function using transthoracic echocardiography in the baboon (Papio hamadryas). METHODS: Transthoracic echocardiography was performed in eight non-pregnant female and six pregnant baboons according to American Society of Echocardiography recommendations. RESULTS: Haemodynamic measurements were obtained from fourteen baboons. Compared to non-pregnant baboons, pregnant baboons demonstrated: (mean ± SD, pregnant vs. healthy) increased cardiac output (1615 ± 121 ml/minutes vs. 1317 ± 134 ml/minutes P = 0.001) due to an increased heart rate [120 ± 11 beats per minute (BPM) vs. 105 ± 6 BPM P = 0.018]. The inter-observer and intra-observer variability (mean difference ± SD) for the left ventricular outflow tract diameter was 0.05 ± 0.07 cm and 0.01 ± 0.03 cm respectively. There was minimal impact to the animal's daily activities. CONCLUSIONS: Transthoracic echocardiography was applicable and reproducible for the assessment of haemodynamics in baboons thus enabling translation of animal results to human studies.
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Dennis et al. (2012) studied this question.
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