The synthesis of axially chiral ζ-amino alcohols 5, carrying a biphenyl moiety, starting from C2 symmetric biphenyl derivatives 1 by a ring opening reaction as the key step is described. Although, evidence is given that enantiomerically pure (P)-1a can be transformed into (P)-5a without loss in enantiomeric purity.
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Furegati et al. (2002) studied this question.