whether or not to consider them familial'. Had Drs Keshavan & Toone chosen to do so, inspection of their data suggests they would have found an even more impressive difference in VBR between their familial and sporadic groups. However, it is import ant to keep in mind an underlying hypothesis before deciding whether one's glass is really half-fullor half empty. If the dependent variable is VBR, then the critical independent variable is not so much the absence of a family history as the presence of earlier environmentally-mediated brain insults which tend to congregate in the sporadic group.
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Freeman et al. (1988) studied this question.
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