Why the study?
Long-term survivors of Hodgkin lymphoma during childhood or adolescence are at high risk of developing treatment-related late cardiovascular sequelae.
Do long-term survivors of childhood or adolescent Hodgkin lymphoma have an increased prevalence of cardiovascular risk factors, endothelial dysfunction, and carotid atherosclerosis compared to healthy volunteers?
Do long-term survivors of childhood or adolescent Hodgkin lymphoma have an increased prevalence of cardiovascular risk factors, endothelial dysfunction, and carotid atherosclerosis compared to healthy volunteers?
Long-term survivors of childhood and adolescent Hodgkin lymphoma exhibit accelerated carotid atherosclerosis, insulin resistance, and unfavorable lipid profiles, underscoring the need for early cardiovascular screening in this population.
Answers are grounded in this paper and cite their sources.
May warrant enhanced CV surveillance in HL survivors; leaves open causal links and intervention efficacy.
Long-term survivors of Hodgkin lymphoma during childhood or adolescence (HL survivors) are at high risk of developing treatment-related late cardiovascular sequelae. In our study we evaluated the presence of modifiable cardiovascular risk factors (hypertension, hyperlipoproteinemia, hyperinsulinemia, obesity), endothelial and inflammatory markers (E-selectin, PAI-1, hs-CRP) and atherosclerotic changes in the common carotid arteries. Assessment was performed in 80 young adult Hodgkin lymphoma long-term survivors at more than 10 years after the potentially cardiovascular toxic anticancer treatment (median age at evaluation 34.7 years; range 24.1-40.9 years). The HL survivors were compared with 83 age- and gender-matched healthy volunteers. The HL survivors showed unfavorable lipid profiles compared to those of healthy controls: triglycerides (p=0.01), total cholesterol (p=0.0004), low density lipoprotein cholesterol (p=0.005). In HL survivors, we found a higher prevalence of hypertension (p=0.004) and insulin resistance - HOMA-IR (p=0.0002). Ultrasonographic examination of both common carotid arteries revealed a higher prevalence of atherosclerotic plaques (p=0.0009) and higher carotid intima-media thickness (p<0.0001) in HL survivors. Markers of oxidative stress (advanced oxidation protein products, oxidized low-density lipoprotein), inflammation (hs-CRP) and endothelial dysfunction (E-selectin, PAI-1) were also higher in HL survivors (p<0.0001, p=0.0002, p=0.0031, p=0.0087, p=0.004, respectively). Adult survivors of Hodgkin lymphoma during childhood and adolescence need closer follow-up with screening of metabolic syndrome components, unfavorable lifestyle factors and early management of these risk factors.
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Čepelová et al. (2019) studied this question.
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