The prevalence of diabetic nephropathy, a seriouscomplication of diabetes, has been increasingworldwide. Therefore, there is an urgent need toidentify a new therapeutic target to prevent di-abetic nephropathy. “Nutrient-sensing ” pathways are gen-erally well conserved among eukaryotes. Accumulating evidence indicates that alteration of nutrient-sensing pathways and subsequent impairment of cell function in insulin-sensitive organs of mammals are involved in the pathogenesis of type 2 diabetes. According to recent reports, nutrient-sensing in the kidney also seems to be altered under diabetic conditions. In this review, we dis-cuss the possibility that nutrient-sensing pathways can be a therapeutic target for diabetic nephropathy and suggest future directions for research.
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Kume et al. (2011) studied this question.
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