What question did this study set out to answer?

Evaluate how reserpine affects heart sensitivity to norepinephrine and accelerans nerve stimulation.

October 17, 1958Science

Estimation of Total Body Fat from Roentgenograms

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Population

Animal model (species not specified)

Design

Preclinical

Authors

JBJosef BrožekUniversity of Minnesota HMHiroyoshi MoriInterventional Cardiology AKAncel KeysGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Findings in animal models warrant caution before clinical extrapolation; extends basic sympathetic transmission concepts but leaves open human relevance.

Key Points

Evaluate how reserpine affects heart sensitivity to norepinephrine and accelerans nerve stimulation.
Administered two doses of reserpine (0.1 mg/kg, intraperitoneally) before testing heart response.
Measured positive chronotropic action of norepinephrine in heart.
Assessed the effect of accelerans nerve stimulation on heart rate.
Reserpine sensitizes the heart to norepinephrine, increasing heart rate.
Reduces heart rate response to accelerans nerve stimulation.
Ganglionic transmission remains unaffected by reserpine.

Structured PICO

Population

Animal model (species not specified)

Intervention

Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally)

Outcome

Chronotropic response to norepinephrine and stimulation of the accelerans nervesurrogate

The presence of peripheral sympathetic transmitter stores is essential for producing tachycardia via accelerans nerve stimulation.

Cite This Study

Brožek et al. (1958) studied this question.

synapsesocial.com/papers/6a70bb41b27f158178277e28 https://doi.org/10.1126/science.128.3329.901-a

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Implication

Findings in animal models warrant caution before clinical extrapolation; extends basic sympathetic transmission concepts but leaves open human relevance.

Estimation of Total Body Fat from Roentgenograms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Estimation of Total Body Fat from Roentgenograms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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