Tissue distribution of diphenylhydantoin and metabolites in oral and nonoral tissues of the ferret after administration of single and multiple doses revealed that prolonged administration resulted in high concentrations of unmetabolized DPH in oral mucosa, salivary glands, and gingiva. This suggests a direct role of unmetabolized DPH in the induced gingival hyperplasia.
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Steinberg et al. (1973) studied this question.
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