The International Sepsis Forum's frontiers in sepsis: High cardiac output should not be maintained in severe sepsis.
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Why the study?
Does targeting supra-normal cardiac output and oxygen delivery reduce mortality in patients with severe sepsis or septic shock?
Population
Patients with severe sepsis or septic shock
Comparison
Goal-directed therapy targeting supra-normal… vs Standard therapy targeting normal hemodynamic…
Design
Review
Authors
Discussion
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Member takes
Implication
Avoid supranormal cardiac output targets in sepsis; leaves open optimal pressure- versus flow-based resuscitation strategies.
Structured PICO
Does targeting supra-normal cardiac output and oxygen delivery reduce mortality in patients with severe sepsis or septic shock?
P
Population
Patients with severe sepsis or septic shock
I
Intervention
Goal-directed therapy targeting supra-normal levels of cardiac output (CO) and oxygen delivery (DO2)
C
Comparator
Standard therapy targeting normal hemodynamic parameters
O
Outcome
Overall mortalityhard clinical
Maintaining supranormal cardiac output and oxygen delivery in severe sepsis does not improve survival and may be harmful, suggesting that maintaining adequate vascular pressure is a more appropriate clinical target.
Cite This Study
Sharma et al. (2003) studied this question.
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