Cumulative catalytic effects of some physiologically active ions on the rate of nitrosation of N‐methylaniline in vitro

There is increasing evidence that foodstuffs and human body fluids containing various amounts of thiocyanate and iodide ions, may significantly increase human exposure to carcinogenic N‐nitrosamines by catalyzing their formation in the digestive tract. We have found that both thiocyanate and iodide ions at physiological concentrations have pronounced cumulative catalytic influence on the in vitro formation of N‐methyl‐N‐nitrosaniline (NMNA).