Superficial Vein Thrombosis of Lower Limbs: Influence of Factor V Leiden, Factor II G20210A and Overweight

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Structured PICO

Population

112 consecutive patients with superficial vein thrombosis (SVT) of lower limbs and 180 healthy donors (controls).

Intervention

Presence of Factor V Leiden, Factor II G20210A, and overweight (BMI >= 28 kg/m2)

Comparator

Absence of these thrombophilic abnormalities and normal weight

Outcome

Superficial vein thrombosis (SVT) of lower limbs

Factor V Leiden and overweight (BMI >= 28 kg/m2) are associated with an increased risk of superficial vein thrombosis of the lower limbs.

Authors

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Supports FV Leiden and overweight as SVT risk factors; hypothesis-generating and requires prospective validation before clinical use.

Wütschert et al. (1998) studied this question.

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